Detection of a Deletion Polymorphism of the Human α2-Macroglobulin Gene (A2M-2) by a Semi-Automated PCR-Single-Stranded Conformational Polymorphism Method
نویسندگان
چکیده
منابع مشابه
A deletion polymorphism in the human alpha-2-macroglobulin (A2M) gene.
Description: Alpha-2-macroglobulin is a major proteinase inhibitor in man. To study the bait domain, which defines the inhibitory spectrum of the protein and which is encoded by two exons (1), primers were designed to amplify the second exon.
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BACKGROUND AND PURPOSE alpha(2)-Macroglobulin may be implicated in amyloid beta protein deposition. A deletion in the exon 18 splice acceptor of the alpha(2)-macroglobulin gene (A2M) has been reported to be associated with risk for Alzheimer's disease (AD). In search of genetic risk factors for cerebral amyloid angiopathy (CAA), we investigated association of the A2M deletion polymorphism with ...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1999
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/45.9.1572